Fig. 2.

A₁R and A_2AR affect body temperature (Temp) in sex-dependent manner. A and B: abbreviations and mice number are the same as in legend to Fig. 1. Temp is recorded for consecutive 10-min periods in mice. The dark period is from 7 PM to 7 AM. C and D: summarizes the corresponding top panels and periods are as described in Fig. 1. The data are shown as a 5-day average and presented as mean values or mean values ± SE (*P < 0.05 compared with WT mice; #P < 0.05 compared with A₁RKO mice; **P < 0.05 compared with A_2ARKO mice; ##P < 0.05 compared with A₁-A_2ARKO mice at the corresponding time period). E: Temp was measured telemetrically during 24 h and recorded for every consecutive 30-min period. The data are shown as a 5-day average and presented as mean values or mean values ± SE (*P < 0.05 compared with corresponding female mice). F: injection of saline (NS), caffeine/enprofylline (Enp) 7.5 mg/kg or 30 mg/kg, was administered intraperitoneally at 2-h intervals in WT1 (F, n = 5; M, n = 6), WT2 (F, n = 8; M, n = 8), A₁RKO (F, n = 8; M, n = 8), A₁-A_2ARKO (F, n = 8; M, n = 9), and A_2ARKO mice (F, n = 8; M, n = 10). Temp is shown as the average from 70 to 80 min after the injection. Data are presented as means ± SE (*P < 0.05 compared with saline injection).