Fig. 3.
A1R and A2AR affect locomotor activity (LA) in sex-dependent manner. Graphs constructed essentially as described in legend to Fig 2. A and B: LA is recorded for consecutive 30-min periods in mice. The dark period is from 7 PM to 7 AM. C and D: summarizes the corresponding top panels. Mean values or mean values ± SE (*P < 0.05 compared with WT mice; #P < 0.05 compared with A1RKO mice; **P < 0.05 compared with A2ARKO mice; ##P < 0.05 compared with A1-A2ARKO mice at the corresponding time period) are given. E: LA were measured telemetrically during 24 h and recorded for every consecutive 30-min periods. The data are shown as a 5-day average and presented as mean values or mean values ± SE (*P < 0.05 compared with corresponding female mice). F: normal saline (NS), caffeine/enprofylline (Enp) 7.5 mg/kg or 30 mg/kg, was administered intraperitoneally at 2-h intervals in WT1 (F, n = 5; M, n = 6), WT2 (F, n = 8; M, n = 8), A1RKO (F, n = 8; M, n = 8), A1-A2ARKO (F, n = 8; M, n = 9), and A2ARKO mice (F, n = 8; M, n = 10). LA is shown as the average from 60 to 90 min after the injection. Data are presented as means ± SE (*P < 0.05 compared with saline injection).