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PE-mediated vascular contraction in endothelium-denuded mouse aortic rings from Gla+/0 and Gla−/0 mice in the absence of COX inhibitor (A) or in the presence of 10−5 mol/l indomethacin (B), 3 mmol/l VS (C), or 10−6 mol/l NS-398 (D). Data are expressed as percentage of contraction elicited by 100 mmol/l KPSS.
