Fig. 4.
Endothelium-independent relaxation mediated by sodium nitroprusside (SNP) in endothelium-intact mouse aortic rings from Gla+/0 and Gla−/0 mice precontracted with an EC80 concentration of PE in the absence of COX inhibitor (A) or in the presence of 10−5 mol/l indomethacin (B), 3 mmol/l VS (C), or 10−6 mol/l NS-398 (D). Data are expressed as percentage of contraction elicited by 100 mmol/l KPSS. *P < 0.05 vs. Gla−/0 (by 2-way ANOVA followed by Bonferroni's post hoc test). †P < 0.05 vs. Gla+/0 + respective treatment (by 2-way ANOVA followed by Bonferonni's post hoc test).