A: mRNA expression of SphK1 and SphK2 in the remote, uninfarcted myocardium (RM) after MI in mouse hearts over time (*P < 0.05, ‡P = 0.08, n = 4–6 animals). B: Western blot of SphK1 and Sphk2 in lysates from the RM, early and late after MI, compared with sham-operated controls. C: SphK1 and -2 protein expression in lysate from the RM, early and late after MI, compared with sham-operated controls.