Fig. 6.

A: binary hearts showed a decreased cardiac myocyte length and a reduced heart weight-to-body weight ratio (H/B). H/B was obtained from mice of each of the 4 genotypes at 12W. The number of mice is indicated within each column. B: cell lengths in binary and CSQ hearts were measured in cardiac myocytes isolated from each genotype. The number of myocytes studied is indicated within each column, and myocytes were isolated from 12W mice (30 WT mice, 37 P2X₄ Tg, 48 CSQ Tg, and 47 binary Tg mice). Data were means and SE. Binary hearts showed lower H/B than did CSQ hearts. Binary cardiac myocytes were shorter than CSQ myocytes. **P < 0.05 when compared with either WT or P2X₄R Tg animals by 1-way ANOVA followed by posttest comparison.