TABLE 3.
Adverse effects associated with perioperative gabapentin use
| Outcome | Number of studies (number of patients) | Relative risk | 95% CI | P | I2 |
|---|---|---|---|---|---|
| Dizziness | 14 (1049) | 1.40 | 1.06 to 1.84 | 0.02 | 0% |
| Sedation* | 12 (905) | 1.65 | 1.00 to 2.74 | 0.05 | 83.3% |
| Respiratory depression* | 2 (406) | 2.05 | 0.37 to 11.26 | 0.41 | 0% |
| Nausea | 17 (1196) | 0.91 | 0.68 to 1.20 | 0.50 | 46.7% |
| Vomiting | 14 (803) | 0.73 | 0.56 to 0.95 | 0.02 | 0% |
| Pruritus | 7 (566) | 0.30 | 0.13 to 0.70 | 0.005 | 0% |
| Urinary retention | 6 (290) | 0.55 | 0.28 to 1.05 | 0.07 | 0% |
*
One study (29) that used an active control (oxazepam 15 mg) was excluded from this analysis