Skip to main content
. 2009 Jan 16;296(4):L565–L573. doi: 10.1152/ajplung.90487.2008

Fig. 5.

Fig. 5.

Expression of lung NAD(P)H:quinone oxidoreductase (NQO1), p21, and IL-6 in Nrf2+/+ and Nrf2−/− newborn mice exposed to hyperoxia. A: lung NQO1 was significantly induced in Nrf2+/+ above room air controls but not in lung of Nrf2−/− mice exposed to hyperoxia. Nrf2+/+ lung NQO1 expression was significantly greater than Nrf2−/− at 48 and 72 h of hyperoxia (*P < 0.01 and **P < 0.0001). B: p21 was induced in lung of both Nrf2+/+ and Nrf2−/− mice in response to hyperoxia. At 72 h of Nrf2+/+ lung p21 expression was significantly greater than Nrf2−/− mice in hyperoxia (*P < 0.01). C: IL-6 was significantly induced in Nrf2−/− mice at 72 h of hyperoxia compared with Nrf2+/+ mice in hyperoxia (*P < 0.0001), n = 3–7 (per group).