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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Cell Cycle. 2008 Sep 17;7(17):2682–2690. doi: 10.4161/cc.7.17.6450

Figure 6.

Figure 6

Potential pathway used by HIV-Tat to cause neurodegeneration. Schematic representation of the pathway used by Tat to cause synaptodendritic injury. Briefly, HIV-1 infects microglia, astrocytes and macrophages. Infected cells release viral proteins including Tat as well as several other toxins such as cytokines and chemokines. Once released from infected cells, proteins/toxins taken up by neuronal cells promote activation of the p53 family members leading to synpatodendritic injury and the development of HAD and/or MCMD.