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. 2009 Apr 15;9:8. doi: 10.1186/1471-2210-9-8

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Copyright © 2009 Lee et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sorafenib, atorvastatin and doxycycline do not affect whole blood rapamycin levels in nude mice bearing Tsc2^-/-tumors. (a) Tumor rapamycin levels from rapamycin treated group (n = 5) and sorafenib plus rapamycin combination treated group (n = 4). (b) Whole blood rapamycin levels from rapamycin treated group (n = 8), atorvastatin plus rapamycin combination treated group (n = 8) and doxycycline plus rapamycin combination treated group (n = 8). Rapamycin levels were measured 24 hours after the last dose of rapamycin for all groups.