Table 5.

Summary of atorvastatin and doxycycline preclinical data

	Untreated	Rapamycin	Atorvastatin	Combination Rapamycin plus Atorvastatin	Doxycycline	Combination Rapamycin plus Doxycycline
Number of mice (n)	8	8	8	8	8	8
Median survival (days)	28	41.5	32.5	55.5	28	43
P value (survival)	-	0.003*	NS*	0.0006* NS#	NS*	0.007* NS#
Day 26, average tumor volume (mm3)	1865 ± 532	544 ± 110	1931 ± 298	390 ± 186	1749 ± 352	1117 ± 421
P value (day 26)	-	0.011*	NS*	0.04*	NS*	NS*
Day 42, average tumor volume (mm3)	-	1784 ± 643	-	1188 ± 338	-	2419 ± 570
P value (day 42)	-	-	-	NS#	-	NS#
Rapamycin (IP, 3 days per week)	-	8 mg/kg, 3 days per week	-	8 mg/kg, 3 days per week	-	8 mg/kg, 3 days per week
Atorvastatin (IP, 5 days per week)	-	-	20 mg/kg per day	20 mg/kg per day	-	-
Doxycycline (IP, 5 days per week)	-	-	-	-	10 mg/kg per day	10 mg/kg per day

*compared to untreated

^#compared to rapamycin treated

NS, not significant