Table 2.
Disease Models | Penetrances (hAA, hAa, haa) | Scenarios | Power in Allelic χ 2test | Power in Genotypic χ 2test | ||||
Null | MCB | UBM | Null | MCB | UBM | |||
I | 0.805 | 0.790 | 0.800 | 0.806 | 0.800 | 0.800 | ||
Dominant | (0.0148, 0.0148, 0.01) | II & III | 0.805 | 0.799 | 0.770 | 0.806 | 0.762 | 0.769 |
IV | 0.805 | 0.730 | 0.762 | 0.806 | 0.756 | 0.759 | ||
I | 0.619 | 0.472 | 0.611 | 0.801 | 0.710 | 0.794 | ||
Recessive | (0.0201, 0.01, 0.01) | II & III | 0.619 | 0.691 | 0.586 | 0.801 | 0.798 | 0.769 |
IV | 0.619 | 0.599 | 0.569 | 0.801 | 0.796 | 0.751 | ||
I | 0.495 | 0.536 | 0.490 | 0.796 | 0.792 | 0.791 | ||
Overdominant | (0.01, 0.0148, 0.01) | II & III | 0.495 | 0.447 | 0.461 | 0.796 | 0.736 | 0.758 |
IV | 0.495 | 0.406 | 0.453 | 0.796 | 0.757 | 0.748 | ||
I | 0.869 | 0.831 | 0.864 | 0.800 | 0.770 | 0.793 | ||
Additive | (0.0178, 0.0139, 0.01) | II & III | 0.869 | 0.880 | 0.840 | 0.800 | 0.776 | 0.763 |
IV | 0.869 | 0.816 | 0.831 | 0.800 | 0.756 | 0.752 | ||
I | 0.875 | 0.831 | 0.870 | 0.800 | 0.763 | 0.793 | ||
Multiplicative | (0.01847, 0.01359, 0.01) | II & III | 0.875 | 0.889 | 0.847 | 0.800 | 0.782 | 0.763 |
IV | 0.875 | 0.826 | 0.838 | 0.800 | 0.759 | 0.752 |
MAF is 0.25 and the sample size in case and control is 500 respectively. Null, the power in absence of missing; MCB, the power affected by missing call bias; UBM, the power when missing equivalently but unbiasedly across different genotypes.