Table 3.
Numbers of transgenic and nontransgenic mice at weaning in each line
| Line | Founder plasma PAI-1† | Generation | Tg+/- mice | Tg-/- mice | % Tg+/- | p value |
|---|---|---|---|---|---|---|
| 1 | 218.0±237.0 | N1 | 17 | 51 | 25% | p<0.0001 |
| N2-5 | 14 | 23 | 38% | p=0.1390 | ||
| 2 | 30.7±17.4 | N1 | 14 | 20 | 41% | p=0.3034 |
| N2-4 | 26 | 37 | 41% | p=0.1657 | ||
| 3 | 1268.8±717.0 | N1 | 0 | 15 | 0% | p<0.0005 |
| 4 | 3.1±0.1 | N1 | 7 | 8 | 47% | p=0.7958 |
| 5 | 80.4±53.2 | N1 | 9 | 15 | 38% | p=0.2207 |
| N2 | 4 | 2 | 67% | p=0.6667 | ||
| 6 | 284.6±328.6 | N1 | 0 | 18 | 0% | p<0.0001 |
| 7 | 280.2±323.5 | N1 | 3 | 38 | 7% | p<0.0001 |
| N2-4 | 31 | 31 | 50% | p=1.0000 | ||
| 8 | 14.2±8.7 | N1 | 13 | 15 | 46% | p=0.7053 |
| N2 | 17 | 27 | 39% | p=0.1316 | ||
| 9 | 15.2±14.7 | N1 | 9 | 14 | 39% | p=0.2971 |
| 10 | 237.8±330.0 | N1 | 0 | 0 | - | - |
| Total | N1 | 72 | 194 | 27% | p<0.0001 | |
| ≥N2 | 92 | 120 | 43% | p=0.0545 |
Significant and suggestive p values are shown in bold.
†
Shown in ng/mL, expressed as mean + SD.