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. Author manuscript; available in PMC: 2009 Apr 20.
Published in final edited form as: J Thromb Haemost. 2007 Oct 8;5(12):2494–2502. doi: 10.1111/j.1538-7836.2007.02785.x

Fig. 8. Ala140 in the GPIX TM domain is not critical to assembly and surface expression of the GPIb-IX complex.

Fig. 8

Ala140 was mutated to Thr, Asp, Lys, or Phe, and the mutational effects on the surface (A) and overall (B) expression level of GPIbα (gray bar) and GPIX (white bar), as well as (C) the effects on GPIb formation were characterized. For some reason, GPIXA140D migrated at a pace different from the other variants. The data shown were either the average or a representative of 4 independent experiments.