Table 3.
Association between hemochromatosis gene status and Barrett’s esophagus
| Mutation status | Number of Barrett’s esophagus/GERD/population | Barrett’s esophagus vs. population controls OR (95% CI)a | Barrett’s esophagus vs. GERD patients OR (95% CI)a |
|---|---|---|---|
| No mutation | 187/207/202 | 1.0 | 1.0 |
| Mild mutationb | 81/63/73 | 1.21 (0.83–1.77) | 1.39 (0.94–2.05) |
| Moderate mutationc | 44/33/26 | 1.75 (1.03–2.97) | 1.40 (0.85–2.31) |
| Severe mutationd | 5/3/7 | 0.77 (0.24–2.48) | 1.90 (0.45–8.12) |
| Any mutatione | 130/99/106 | 1.32 (0.95–1.84) | 1.41 (1.01–1.97) |
| Moderate or severe mutation | 49/36/33 | 1.54 (0.94–2.52) | 1.45 (0.90–2.33) |
a
Odds ratios are adjusted for gender, age, ethnicity, and smoking status
b
Wild type/H63D
c
C282Y/wild type, H63D/H63D
d
C282Y/H63D, C282Y/C282Y
e
Any subject without wild type/wild type