Table 4.
Evaluation of whether subjects with hemochromatosis gene defects are at increased risk of higher iron stores: hemochromatosis gene status, serum iron saturation, and serum ferritin concentration
| Mutation status | Barrett’s esophagus/GERD/population | Among all subjects | Among Barrett’s esophagus | Among GERD group | Among controls |
|---|---|---|---|---|---|
| Odds of being in fourth quartile of iron saturation (95% confidence interval)a,b | |||||
| No mutation | 187/207/202 | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| Any mutation | 130/99/106 | 1.99 (1.36–2.91) | 1.61 (0.86–3.02) | 3.03 (1.54–5.99) | 1.74 (0.85–3.55) |
| Moderate or severe mutationc | 49/36/33 | 2.88 (1.63–5.06) | 2.40 (1.00–5.78) | 5.45 (1.84–16.18) | 1.99 (0.68–5.81) |
| Odds of being in fourth quartile of ferritin (95% confidence interval)a,d | |||||
| No mutation | 187/207/202 | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| Any mutation | 130/99/106 | 1.25 (0.84–1.87) | 1.88 (0.91–3.87) | 0.79 (0.37–1.68) | 1.74 (0.80–3.77) |
| Moderate or severe mutationc | 49/36/33 | 1.39 (0.78–2.48) | 2.62 (1.04–6.56) | 1.22 (0.42–3.51) | 1.34 (0.38–4.76) |
a
Odds ratios are adjusted for gender, age, ethnicity, and smoking status
b
Odds of being in the fourth quartile (median 31%) vs. first quartile (median 12%) of percent transferrin saturation; quartiles are based on the control population distributions
c
C282Y/wild type, H63D/H63D, C282Y/H63D, C282Y/C282Y
d
Odds of being in the fourth quartile (median 291 ng/ml) vs. first quartile (median 38 ng/ml) of ferritin concentration; quartiles are based on the control population distributions