Table 1.
Participant demographics by diagnostic group
| Characteristic | UHR OCD+ N = 13 | UHR OCD- N = 51 | NPC N = 26 |
|---|---|---|---|
| Age at examination, mean (± SD), [range] | 15.58 (2.03), [12.67-18.08] | 16.68 (2.39), [12.25-21.75] | 17.67 (2.33), [13.75-21.50] |
| Female Gender, n (%) | 6 (46%) | 19 (37%) | 15 (58%) |
| Caucasian, n (%) | 8 (62%) | 28 (56%) | 12 (46%) |
| Level of Education, mean (± SD), [range] | 9.23 (1.88), [6-12] | 9.86 (2.12), [6-15] | 11.28 (2.17), [7-15] |
| Primary SIPS-defined Prodromal Status, n (%) | |||
| Brief Intermittent Psychotic Syndrome | 2 (15%) | 10 (20%) | N/A |
| Attenuated Positive Symptom Syndrome | 11 (85%) | 40 (78%) | N/A |
| Genetic Risk & Deterioration Syndrome | 0 (0%) | 1 (2%) | N/A |
| Padua Inventory a | |||
| Total score, mean (± SD), [range] | 46.56 (43.39), [6-129] | 39.95 (35.89), [0-161] | 9.76 (9.36), [0-35] |
| Factor 1: Mental Control, mean (±SD), [range] | 13.56 (13.46), [0-38] | 15.38 (14.09), [0-49] | 2.14 (2.39), [0-10] |
| Factor 2: Contamination, mean (±SD), [range] | 12.11 (10.45), [2-29] | 7.38 (7.28), [0-27] | 4.57 (5.24), [0-20] |
| Factor 3: Checking, mean (±SD), [range] | 6.56 (8.06), [0-22] | 4.43 (5.36), [0-26] | 0.90 (1.30), [1-3] |
| Factor 4: Motor Control, mean (±SD), [range] | 3.22 (5.31), [0-16] | 2.48 (3.50), [0-15] | 0.29 (0.64), [1-2] |
| Clinical Characteristics of Sample | |||
| Converted at Follow-up, n (%) | 0 (0%) | 11 (22%) | N/A |
| SIPS Positive Symptom Total, mean (±SD), [range] | 12.46 (4.01), [5-19] | 11.51 (4.70), [1-22] | 1.58 (1.88), [0-6] |
| SIPS Negative Symptom Total, mean (±SD), [range] | 13.00 (5.39), [3-22] | 13.12 (7.55), [2-30] | 1.23 (1.77), [0-7] |
| SIPS Disorganized Symptom Total, mean (±SD), [range] | 6.54 (3.99), [2-15] | 5.90 (3.13), [0-15] | 1.0 (1.30), [0-5] |
| SIPS General Symptom Total, mean (±SD), [range] | 8.46 (3.76), [2-13] | 7.53 (4.32), [0-16] | 0.88 (1.11), [0-3] |
| BPRS Depression score, mean (±SD), [range] | 3.08 (1.75), [1-6] | 3.08 (1.71), [1-7] | 1.16 (0.38), [1-2] |
| BPRS Suicidality score, mean (±SD), [range] | 2.00 (1.00), [1-4] | 1.72 (1.13), [1-5] | 1.00 (0.0), [1-1] |
| BDI Total Score, mean (± SD), [range] | 14.25 (14.14), [2-38] | 14.78 (11.03), [1-42] | 3.59 (3.61), [0-14] |
| Global Social Functioning Scale score, mean (± SD), [range] | 6.00 (1.16), [4-7] | 5.62 (1.63), [2-8] | 8.72 (0.84), [6-10] |
| Global Role Functioning Scale score, mean (±SD), [range] | 5.31 (1.84), [3-8] | 5.22 (1.85), [1-9] | 8.48 (1.12), [4-10] |
| GAF score, mean (± SD), [range] | 47.62 (5.36), [40-58] | 44.51 (14.16), [18-70] | 81.54 (10.31), [48-95] |
| Treatment Characteristics | |||
| History of Hospitalization, n (%) | 4 (31%) | 22 (43%) | N/A |
| Current Use of Any Medication, n (%) | 9 (69%) | 35 (71%) | N/A |
| Current Atypical Antipsychotic Use1, n (%) | 4 (31%) | 21 (41%) | N/A |
| Past Atypical Antipsychotic Use, n (%) | 5 (39%) | 21 (41%) | N/A |
| Current SSRI Use1, n (%) | 8 (62%) | 20 (39%) | N/A |
| Past SSRI Use, n (%) | 6 (46%) | 25 (49%) | N/A |
a
Sample sizes for Padua Inventory analyses are as follows: UHR OCD+ n=9; UHR OCD- n=40, NPC n=2. Data reported in table is not transformed.
1
Atypical Antipsychotic medications included: Aripiprazole, Ziprasidone, Risperidone, Olanzapine, and Quetiapine.