Table 3.

Relationship between Aβ levels in 1998–1999 and incident mild cognitive impairment in 2002–2003 in normal subjects (all subjects)

	Model 1		Model 2		Model 3		Model 4
	OR (95% CI)	p Value	OR (95% CI)	p Value	OR (95% CI)	p Value	OR (95% CI)	p Value
Aβ-40	1.39 (0.99–1.96)	0.05	1.34 (0.95–1.89)	0.09	1.47 (1.00–2.16)	0.05	1.61 (1.03–2.53)	0.03
Aβ-42	1.30 (0.93–1.83)	0.13	1.27 (0.90–1.79)	0.17	1.28 (0.90–1.83)	0.17	1.34 (0.90–1.99)	0.14
Aβ-42/Aβ-40	1.07 (0.78–1.49)	0.66	1.07 (0.77–1.49)	0.66	1.04 (0.75–1.45)	0.80	1.06 (0.74–1.54)	0.74

Model 1: unadjusted; Model 2: adjusted for age; Model 3: adjusted for age and cystatin C level; Model 4: adjusted for age, Modified Mini-Mental State Examination scores, cystatin C, APOE-4, and MRI identified infarcts. The odds ratios (ORs) were estimated with increments of 1 SD of plasma Aβ1-40 and Aβ1-42.