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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2008 Jul;7(7):1985–1992. doi: 10.1158/1535-7163.MCT-07-2104

Figure 1.

Figure 1

DMAG sensitizes lung cancer cell lines to radiation. A, dose-finding assay. Colony formation assay of H460 cells treated with increasing concentrations of DMAG for 16 h before radiation. Surviving fractions were calculated as plating efficiency-treated divided by plating efficiency-control in triplicate. Average ±SD. Cells treated with DMAG alone (white columns) or in combination with 2 Gy radiation (black columns). B, surviving fraction as measured by clonogenic assay of H460 cells exposed to 0, 2, 4, or 6 Gy radiation alone (dashed lines) or in the presence of 100 nmol/L DMAG (solid lines). Cells were radiated simultaneously (circles), after 8 h (triangles), or after 16 h (squares) treatment with DMAG. C, surviving fraction of A549 cells exposed to radiation alone (dashed line) or combination therapy (solid line) using simultaneous (circles) or 16-h pretreatment (squares) with DMAG. Results are normalized to untreated cells and presented as ±SD of triplicate samples. Results for one of three or more independent experiments.