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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2008 Jul;7(7):1985–1992. doi: 10.1158/1535-7163.MCT-07-2104

Figure 4.

Figure 4

Radiation-induced DNA damage repair is impaired in cells pretreated with DMAG. A, DNA damage as quantified by alkaline comet assay. Percent of cells with DNA damage above the average for control untreated cells. B, tail moments above the mean values of untreated cells. Cells were treated with radiation alone (open circles) or radiation after exposure to DMAG for 16 h (closed circles). Results are means from counts of 50 random cells done in triplicate samples. C, Western blot analysis of ATM, HSP70, APE1, and Pol-β. Cell extracts were harvested at indicated times relative to sham-treated control cells. Results from one of two independent experiments.