Table 2.

Total sample size and power with respect to the proportion of patients with a matched sibling donor (i.e., patients assigned to the auto-allo arm). The number of auto-allo patients is fixed at 150. Power is calculated to detect a difference between the auto-allo arm and the auto-auto arm with respect to three year progression-free survival (PFS) rates of 60% (auto-allo) vs. 45% (auto-auto). A two-sided type I error rate of 5% is used with no correction for interim analyses.

Proportion with Matched Sibling Donor	Number on auto-allo arm	Number on auto-auto arm	Total n	Power
0.20	150	600	750	91%
0.25	150	450	600	89%
0.30	150	350	500	87%