Table 3.

Monitoring plan for the proportion of patients enrolled to the auto-allo arm at a particular transplant center. Monitoring plan is based on a Sequential Probability Ratio Test testing the null hypothesis that the true (i.e., asymptotic) proportion of enrolled patients with a matched sibling donor is 25% against the alternative hypothesis that the proportion is 10%. A 10% type I error rate and a 20% type II error rate are used.

Total Enrolled	Enrolled to the auto-allo arm
0 - 11	No review
12 - 17	Review if 0 patients enrolled to the auto-allo arm
18 - 23	Review if 1 or fewer patients enrolled to the auto-allo arm
24 - 29	Review if 2 or fewer patients enrolled to the auto-allo arm
30 - 35	Review if 3 or fewer patients enrolled to the auto-allo arm
36 - 41	Review if 4 or fewer patients enrolled to the auto-allo arm
42 - 47	Review if 5 or fewer patients enrolled to the auto-allo arm
48 - 53	Review if 6 or fewer patients enrolled to the auto-allo arm