Table 1.
Conservation of Sin3, NuRD, CoREST and NCoR/SMRT components in the Metazoa.
| Complex | C. elegans | D. melanogaster | Vertebrates |
|---|---|---|---|
| Sin3 | HDA-1 | RPD3 | HDAC1, HDAC2 |
| RBA-1, LIN-53 | p55 | RbAp46, RbAp48 | |
| SIN-3 | Sin3 | Sin3A | |
| MAB-21 | mab-21 | mab21L1, mab21L2 | |
| Sds3 | Sds3, BRMS1 | ||
| RBP1 | |||
| SAP18 | Bin1 | SAP18 | |
| SAP30 | |||
| ING1/2 | |||
| Mi2/NuRD | HDA-1 | RPD3 | HDAC1, HDAC2 |
| RBA-1, LIN-53 | p55 | RbAp46, RbAp48 | |
| LET-418, CHD-3 | Mi-2 | Mi-2α, Mi-2β | |
| Atrophin? | MTA1, MTA-2, Atrophin-2? | ||
| MBD2/3 | MBD3 | ||
| p66 | p66α, p66β | ||
| MEP-1 | CG1244 | ||
| CoREST | HDA-1 | RPD3 | HDAC1, HDAC2 |
| SPR-1 | CoREST | CoREST | |
| SPR-5 | Hdm | LSD1 | |
| SPR-3, SPR-4 | REST | ||
| DIN-1 | Spen | SHARP | |
| BHC80 | |||
| SIN3 | |||
| SMRT/NCoR | HDAC3 | HDAC3 | |
| SMRTER | SMRT/NCoR | ||
| Ebi | TBL1, TBL1R | ||
| GPS2 | |||
| JMJD2A | |||
Putative orthologues without functional data are indicated in italics.