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. 2009 Feb 10;58(5):1192–1200. doi: 10.2337/db08-1266

TABLE 1.

Growth and hormonal data, age 3 weeks

C-C C-U U-C U-U
Birth weight (g) 1.59 ± 0.01 1.56 ± 0.03 1.23 ± 0.05* 1.09 ± 0.02*
Body weight (g) 16.4 ± 1.1 7.7 ± 0.8* 17.8 ± 0.7 8.4 ± 0.9*
Body length (cm) 7.8 ± 0.1 6.0 ± 0.2* 7.7 ± 0.1 6.2 ± 0.2*
Gonadal fat weight (g) 0.18 ± 0.02 0.018 ± 0.004* 0.25 ± 0.03§ 0.041 ± 0.005*
Gonadal fat/body weight (%) 1.1 ± 0.1 0.22 ± 0.04* 1.4 ± 0.1§ 0.40 ± 0.04*
Sum of fat pad weights/body weight (%)# 2.8 ± 0.2 0.5 ± 0.1* 3.7 ± 0.3§ 1.2 ± 0.1§
Blood glucose (mmol/l) 8.9 ± 0.2 5.5 ± 0.5§ 8.2 ± 0.3 6.1 ± 1.1§
Corticosterone (ng/ml) 151 ± 18 234 ± 14 167 ± 21 341 ± 63
Insulin (pmol/l) 445 ± 70 115 ± 35§ 545 ± 100 275 ± 40§
T4 (μg/dl) 8.7 ± 0.7 7.1 ± 0.9 8.8 ± 0.8 6.1 ± 0.2*
T4 resin binding (%) 40.8 ± 1.2 40.0 ± 1.6 41.5 ± 1.5 36.2 ± 1.6*
Leptin (ng/dl) 6.1 ± 0.4 0.8 ± 0.2* 5.9 ± 0.4 2.0 ± 0.5*
Adiponectin (ng/ml) 7.8 ± 1.2 13.3 ± 4.1* 5.2 ± 0.9 8.9 ± 1.1
Resistin (ng/ml) 2.6 ± 0.3 1.3 ± 0.1* 2.0 ± 0.2§ 1.9 ± 0.3§
IL-6 (pg/ml) 4.0 ± 0.3 5.2 ± 0.9 4.8 ± 1.1 4.7 ± 0.5
MCP-1 (pg/ml) 47 ± 4 60 ± 8 36 ± 6 49 ± 8
PAI-1 (ng/ml) 4.5 ± 0.4 5.9 ± 0.2§ 3.6 ± 0.3 4.4 ± 0.6
TNF-α (pg/ml) 9.5 ± 0.5 8.4 ± 0.4 9.1 ± 0.4 10.9 ± 1.2

Data are means ± SE. Growth data, glucose homeostasis, and hormonal data in male mice, age 3 weeks. n = 5–9 per group, depending on the assay. Multigroup comparisons were done by ANOVA, and pairwise comparisons were done by Fisher's protected least-significant difference.

*P < 0.001 vs. C-C;

P < 0.05 vs. U-C;

P < 0.001 vs. U-C;

§P < 0.05 vs. C-C;

P < 0.01 vs. C-C;

P < 0.01 vs. U-C;

#sum of weight of gonadal, subcutaneous flank, and perirenal fat pads.