TABLE 1.
Growth and hormonal data, age 3 weeks
C-C | C-U | U-C | U-U | |
---|---|---|---|---|
Birth weight (g) | 1.59 ± 0.01 | 1.56 ± 0.03 | 1.23 ± 0.05* | 1.09 ± 0.02*† |
Body weight (g) | 16.4 ± 1.1 | 7.7 ± 0.8*‡ | 17.8 ± 0.7 | 8.4 ± 0.9*‡ |
Body length (cm) | 7.8 ± 0.1 | 6.0 ± 0.2*‡ | 7.7 ± 0.1 | 6.2 ± 0.2*‡ |
Gonadal fat weight (g) | 0.18 ± 0.02 | 0.018 ± 0.004*‡ | 0.25 ± 0.03§ | 0.041 ± 0.005*‡ |
Gonadal fat/body weight (%) | 1.1 ± 0.1 | 0.22 ± 0.04*‡ | 1.4 ± 0.1§ | 0.40 ± 0.04*‡ |
Sum of fat pad weights/body weight (%)# | 2.8 ± 0.2 | 0.5 ± 0.1*‡ | 3.7 ± 0.3§ | 1.2 ± 0.1§ |
Blood glucose (mmol/l) | 8.9 ± 0.2 | 5.5 ± 0.5§ | 8.2 ± 0.3 | 6.1 ± 1.1§ |
Corticosterone (ng/ml) | 151 ± 18 | 234 ± 14 | 167 ± 21 | 341 ± 63‖¶ |
Insulin (pmol/l) | 445 ± 70 | 115 ± 35§ | 545 ± 100 | 275 ± 40§ |
T4 (μg/dl) | 8.7 ± 0.7 | 7.1 ± 0.9 | 8.8 ± 0.8 | 6.1 ± 0.2*† |
T4 resin binding (%) | 40.8 ± 1.2 | 40.0 ± 1.6 | 41.5 ± 1.5 | 36.2 ± 1.6*† |
Leptin (ng/dl) | 6.1 ± 0.4 | 0.8 ± 0.2*‡ | 5.9 ± 0.4 | 2.0 ± 0.5*‡ |
Adiponectin (ng/ml) | 7.8 ± 1.2 | 13.3 ± 4.1*¶ | 5.2 ± 0.9 | 8.9 ± 1.1 |
Resistin (ng/ml) | 2.6 ± 0.3 | 1.3 ± 0.1* | 2.0 ± 0.2§ | 1.9 ± 0.3§ |
IL-6 (pg/ml) | 4.0 ± 0.3 | 5.2 ± 0.9 | 4.8 ± 1.1 | 4.7 ± 0.5 |
MCP-1 (pg/ml) | 47 ± 4 | 60 ± 8 | 36 ± 6 | 49 ± 8 |
PAI-1 (ng/ml) | 4.5 ± 0.4 | 5.9 ± 0.2§ | 3.6 ± 0.3 | 4.4 ± 0.6 |
TNF-α (pg/ml) | 9.5 ± 0.5 | 8.4 ± 0.4 | 9.1 ± 0.4 | 10.9 ± 1.2 |
Data are means ± SE. Growth data, glucose homeostasis, and hormonal data in male mice, age 3 weeks. n = 5–9 per group, depending on the assay. Multigroup comparisons were done by ANOVA, and pairwise comparisons were done by Fisher's protected least-significant difference.
*P < 0.001 vs. C-C;
†P < 0.05 vs. U-C;
‡P < 0.001 vs. U-C;
§P < 0.05 vs. C-C;
‖P < 0.01 vs. C-C;
¶P < 0.01 vs. U-C;
#sum of weight of gonadal, subcutaneous flank, and perirenal fat pads.