TABLE 1.

Metabolic parameters in hGPR40 transgenic (47M and 23F) mice fed a regular diet or a high-fat diet

	Body weight (g)	Plasma glucose (mg/dl)	Plasma insulin (ng/ml)	Plasma NEFA (mEq/l)
Regular diet
Fed
Nontransgenic	28.8 ± 0.4	170.0 ± 4.1	1.54 ± 0.30	0.33 ± 0.08
Transgenic(47M)	27.5 ± 0.6	153.6 ± 6.2	1.61 ± 0.43	0.24 ± 0.06
Nontransgenic	28.7 ± 0.4	187.6 ± 9.8	1.43 ± 0.38	0.37 ± 0.08
Transgenic (23F)	28.1 ± 0.3	161.4 ± 8.1	1.46 ± 0.38	0.41 ± 0.06
Fasted
Nontransgenic	24.3 ± 0.4	106.0 ± 4.8	0.19 ± 0.04	1.35 ± 0.06
Transgenic (47M)	22.9 ± 0.6	84.5 ± 4.4*	0.23 ± 0.05	1.00 ± 0.07
Nontransgenic	24.0 ± 0.3	117.7 ± 5.0	0.21 ± 0.03	1.07 ± 0.07
Transgenic (23F)	23.6 ± 0.3	89.9 ± 5.2*	0.24 ± 0.05	0.98 ± 0.07
High-fat diet
Fed
Nontransgenic	49.9 ± 0.7	215.6 ± 8.1	18.87 ± 3.52	0.52 ± 0.04
Transgenic (47M)	49.6 ± 1.0	212.8 ± 9.9	16.17 ± 2.95	0.49 ± 0.03
Fasted
Nontransgenic	46.0 ± 0.6	173.8 ± 5.6	2.88 ± 0.31	0.80 ± 0.04
Transgenic (47M)	45.4 ± 0.9	133.3 ± 4.5*	3.07 ± 0.39	0.80 ± 0.04

All parameters were measured in the fed and fasted states at 16 weeks of age on a regular diet. The hGPR40 transgenic (47M) and nontransgenic mice were fed a high-fat diet containing 60 kcal% fat for 12 weeks. All parameters were measured in the fed and fasted state at 20 weeks of age. All values are the means ± SE, n = 7–10 per genotype. *P ≤ 0.01 vs. nontransgenic mice by Student's t test.