FIG. 5.

Effects of compound C on insulin-stimulated (A) and AICAR-stimulated (B) glucose transport. Paired isolated rat epitrochlearis muscles were incubated with or without 40 μmol/l of compound C for 60 min. Muscles were then either incubated in identical media (basal) or in solution that contained 2,000 μU/ml of insulin (A) for 20 min or in solution that contained 2 mmol/l of AICAR (B) for 40 min and used for 3-MG transport measurement. Data are the means ± SE, n = 6–14 per group. Post hoc analysis: *P < 0.05 (effect of insulin or AICAR); †P < 0.05 (effect of compound C). □, DMSO; ■, compound C.