TABLE 2.
Change in anthropometric, metabolic, and hemodynamic parameters after a 12-week lifestyle intervention
| Whole group | Insulin sensitive | Insulin resistant | |
|---|---|---|---|
| n | 34 | 15 | 19 |
| Body weight (kg) | −8.2 ± 0.7‡ | −8.4 ± 1.1‡ | −8.1 ± 0.9‡ |
| Waist circumference (cm) | −8.6 ± 0.8‡ | −9.8 ± 1.3‡ | −7.6 ± 0.9‡ |
| Total body fat mass (kg) | −6.4 ± 0.6‡ | −6.9 ± 1.1‡ | −6.0 ± 0.7‡ |
| Trunk fat mass (kg) | −3.9 ± 0.4‡ | −4.1 ± 0.8‡ | −3.7 ± 0.6‡ |
| Triglyceride (mmol/l) | −0.7 ± 0.1‡ | −0.9 ± 0.2‡ | −0.6 ± 0.2‡ |
| HDL cholesterol (mmol/l) | −0.06 ± 0.03* | −0.06 ± 0.05 | −0.06 ± 0.03 |
| Fasting glucose (mmol/l) | −0.6 ± 0.1‡ | −0.5 ± 0.1‡ | −0.7 ± 0.1‡ |
| Fasting insulin (mU/l) | −4 ± 1‡ | −3 ± 1* | −5 ± 1‡ |
| Insulin AUC0–20 (mU l−1 · min−1) | −2,232 ± 428‡ | −1,543 ± 489* | −2,913 ± 626† |
| Whole-body SI | 1.11 ± 0.29‡ | 1.6 ± 0.5‡ | 0.7 ± 0.2‡ |
| Fasting leptin (ng/ml) | −7.4 ± 1.4‡ | −5.7 ± 2.2‡ | −8.7 ± 1.9‡ |
| hsCRP (mg/l) | −0.4 ± 0.2* | −0.5 ± 0.3 | −0.4 ± 0.3 |
| Urinary sodium (mmol/day) | −35 ± 10† | −35 ± 17 | −35 ± 12* |
| Systolic blood pressure (mmHg) | −11 ± 2‡ | −13 ± 3‡ | −10 ± 2‡ |
| Diastolic blood pressure (mmHg) | −4 ± 1‡ | −5 ± 2† | −3 ± 1* |
| Heart rate (bpm) | −4 ± 1† | −3 ± 2 | −5 ± 2† |
| Vo2/FFM (ml · min−1 · kg−1) | 2.2 ± 0.7† | 2.0 ± 0.9 | 2.3 ± 1.2* |
| Resting calf blood flow (ml · min−1 · 100 ml−1) | −0.14 ± 0.12 | −0.06 ± 0.20 | −0.20 ± 0.16 |
Data are means ± SE.
*P < 0.05,
†P ≤0.01,
‡P ≤0.001 vs. baseline by two-way repeated-measures ANOVA and Holm-Sidak pairwise comparisons. Blood pressures are the average of five supine Dinamap recordings (model 1846 SX; Critikon, Tampa, FL). SI, insulin sensitivity index.