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. 2009 Feb 10;58(5):1133–1143. doi: 10.2337/db08-0245

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© 2009 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 4. — Insulin resistance was normalized in HFD-fed homozygous Mstn mutant animals to levels of standard diet–fed mice. A: Insulin tolerance test. B and C: Glucose tolerance test. ♦, HFD Mstn^+/Ln; □, HFD Mstn^Ln/Ln; ▴, standard diet Mstn^Ln/Ln. HFD blood glucose was monitored during the glucose tolerance test (B) or insulin measured thereafter (C). Data are shown as means ± SE for males (n = 8) and females (n = 6). D: The HOMA-IR was calculated from the glucose tolerance data as described in research design and methods. Insulin resistance was adjusted for lean mass compared with male heterozygous mice. Level of insulin resistance was different at P < 0.01 compared with same sex Mstn^+/Ln (*) or males Mstn^+/Ln (**). Bars represent the means ± SE of insulin resistance calculated from AUCs.