TABLE 1.

Body composition of 4-month-old mice after being weaned onto HFD or standard diet

	n	Weight (g)
		Fat	Lean	Body
Male
Mstn+/+ genotype
HFD	10	8.2 ± 1.39*†	21.9 ± 0.69*	32.3 ± 1.37*†
Standard diet	7	3.2 ± 0.53	21.7 ± 1.21	28.3 ± 1.45
Mstn+/Ln genotype
HFD	34	6.4 ± 0.43*‡	26.5 ± 0.43*‡	36.3 ± 0.46*‡
Standard diet	5	3.1 ± 0.33	23.8 ± 0.47	30.3 ± 0.68
MstnLn/Ln genotype
HFD	28	0.70 ± 0.11*	33.6 ± 0.53*‡	36.9 ± 0.54*‡
Standard diet	8	0.45 ± 0.08	27.2 ± 0.68	29.5 ± 0.68
Female
Mstn+/+ genotype
HFD	6	5.0 ± 0.47†	18.2 ± 0.28	25.7 ± 0.61†
Standard diet	8	2.0 ± 0.07	17.7 ± 0.32	22.1 ± 0.42
Mstn+/Ln genotype
HFD	15	4.9 ± 0.33†	18.8 ± 0.28	26.2 ± 0.51†
Standard diet	9	2.3 ± 0.14	19.1 ± 0.36	23.6 ± 0.47
MstnLn/Ln genotype
HFD	8	1.99 ± 0.14†	24.3 ± 0.44†	28.2 ± 0.41‡
Standard diet	6	1.21 ± 0.06	22.1 ± 0.41	24.9 ± 0.46

Data are means ± SE.

*P < 0.05 vs. HFD female mice;

†P < 0.05;

‡P < 0.01 vs. mice of the same sex and genotype on standard diet.