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. 2009 Feb 10;58(5):1156–1164. doi: 10.2337/db08-0800

FIG. 4.

FIG. 4.

The role of CD4 T-cells. A: 3H-Thymidine incorporation proliferation assay of CD8, CD4, and mixed CD8 and CD4 splenocytes from G9Cα−/−.NOD mice in response to B15-23 peptide G9Cα−/−. B: Adoptive transfer of purified CD4 T-cells of splenocytes from diabetic NOD intravenously into 4-week-old G9Cα−/−.NOD mice (n = 16). No diabetes occurred in mice adoptively transferred with CD4 T-cells purified from young NOD mice (n = 5). P < 0.018 when both groups were compared. The mice were tested weekly for glycosuria and diabetes confirmed by blood glucose of >13.9mmol/l.