Table 1.

Effects of various growth factors on adult hippocampal neurogenesis. Abbreviations: FGF-1R (fibroblast growth factor-1 receptor), FGF-2 (fibroblast growth factor-2), i.c.v. (intracerebraventricular), IGF-I (insulin-like growth factor one), LID (liver insulin deficient), VEGF (vascular endothelial growth factor).

Growth Factor	Species	Manipulation	Proliferation	Differentiation	Survival	Reference
EGF	Rat	i.c.v. (14 days)	↔	—	—	Kuhn et al., 1997
FGF-2	Rat	i.c.v. (14 days)	—	—	↑ a	Rai et al., 2007
	Mouse	FGF-1R (-/-)	↓	↓ Neurons, glia	↓	Zhao et al., 2007a
	Mouse	FGF-2 (-/-)	↔	↔	↔	Yoshimura et al., 2001
IGF-I	Rat (aged)	i.c.v. (Chronic)	↑	↔	↑	Lichtenwalner et al., 2001
	Rat	Peripheral (Chronic)	↑	↑ Neurons	↑	Aberg et al., 2000; Aberg et al., 2003
	Mouse	LID	↔	↔	↓	Trejo et al., 2007
VEGF	Rat	i.c.v. (3 days)	↑ b	—	—	Jin et al., 2002
	Rat	i.c.v. (8 days)	↔	↔	↑	Schanzer et al., 2004

^aSacrificed 10d after last BrdU injection

^bSacrificed 7d after last BrdU injection