Table 2.
Regulation of adult hippocampal neurogenesis by neurotrophic factors. Abbreviations: BDNF (brain derived neurotrophic factor), CNTF (ciliary neurotrophic factor), NT-3,-4 (neurotrophin-3,-4), NGF (nerve growth factor)
| Neurotrophin | Species | Manipulation | Proliferation | Differentiation | Survival | Reference |
|---|---|---|---|---|---|---|
| BDNF | Rat | Intrahippocampal (14 days) | — | — | ↑ | Scharfman et al., 2005 |
| BDNF (+/-) | ↓ | — | ↓ | Lee et al., 2002 | ||
| BDNF (+/-) | ↑ | — | ↓ | Sairanen et al., 2005 | ||
| Truncated TrkB transgenic | ↑ | — | ↓ | Sairanen et al., 2005 | ||
| NT-3 | Mouse | NT-3 (-/-) | ↔ | ↓ Neurons | ↔ | Shimazu et al., 2006 |
| NT-4 | Mouse | NT-4 (-/-) | — | ↔ | ↔ | Rossi et al., 2006 |
| CNTF | Mouse | Intrafrontalcortical (single injection) | ↑ a | ↑ Neurons | ↔ | Emsley and Hagg, 2003 |
| NGF | Rat | i.c.v. | ↔ | ↔ | ↑ | Frielingsdorf et al., 2007 |
a
Sacrificed 10d after last BrdU injection