Table 2.
Estimated crude (95% CI) and adjusted least-squares mean biomarker concentrations by CCI category for women (n = 984) with diabetes
| CCI (0–16 points) |
P trend | |||
|---|---|---|---|---|
| 0 or 1 | 2–3 | ≥4 | ||
| n | 288 | 318 | 378 | |
| Adiponectin (μg/ml) | 5.7 (5.3–6.2) | 6.2 (5.7–6.7) | 5.5 (5.1–5.9) | 0.35 |
| Model 1 | 5.4 | 5.7 | 5.3 | 0.68 |
| Model 2 | 5.0 | 5.4 | 5.1 | 0.78 |
| Model 3 | 6.0 | 6.6 | 6.4 | 0.34 |
| Leptin (ng/ml) | 34.7 (31.6–38.2) | 33.1 (30.2–36.2) | 40.9 (37.7–44.4)*† | 0.006 |
| Model 1 | 41.6 | 41.7 | 46.6 | 0.01 |
| Model 2 | 37.0 | 38.1 | 43.3*† | 0.002 |
| Model 3 | 37.3 | 38.3 | 43.4*† | 0.004 |
| CRP (mg/l) | 3.7 (3.3–4.1) | 3.6 (3.2–3.9) | 4.2 (3.8–4.6) | 0.06 |
| Model 1 | 4.1 | 4.1 | 4.5 | 0.11 |
| Model 2 | 4.4 | 4.5 | 4.7 | 0.25 |
| Model 3 | 4.4 | 4.5 | 4.7 | 0.38 |
| sE-selectin (ng/ml) | 59.0 (55.7–62.4) | 55.1 (57.8–57.7) | 61.5 (58.5–64.6)† | 0.20 |
| Model 1 | 61.2 | 57.6 | 63.4† | 0.27 |
| Model 2 | 61.4 | 57.6 | 63.1 | 0.40 |
| Model 3 | 54.7 | 50.5 | 55.9† | 0.43 |
| sICAM-1 (ng/dl) | 295 (284–306) | 291 (281–302) | 312 (302–322) † | 0.02 |
| Model 1 | 290 | 288 | 307*† | 0.01 |
| Model 2 | 325 | 318 | 340† | 0.07 |
| Model 3 | 311 | 303 | 325† | 0.08 |
| sTNF-αRII (pg/ml) | 2,397 (2,318–2,480) | 2,382 (2,307–2,461) | 2,516 (2,443–2,591)† | 0.03 |
| Model 1 | 2,481 | 2,490 | 2,611 | 0.02 |
| Model 2 | 2,416 | 2,424 | 2,529 | 0.04 |
| Model 3 | 2,487 | 2,495 | 2,629† | 0.01 |
Model 1: adjusted for age, BMI, and race; model 2: adjusted additionally for physical activity, total energy intake, alcohol intake, smoking status, full-time work status, education level, and marital status; model 3: adjusted additionally for hypertension, hypercholesterolemia, A1C, family history of diabetes, aspirin, postmenopausal hormone, insulin, oral diabetes medication use, sleep duration, and duration of diabetes.
*Significantly different from group 1 (Bonferroni-adjusted P value <0.05).
†Significantly different from group 2 (Bonferroni-adjusted P value <0.05).