Table 2.
Unadjusted and adjusted HRs of developing microalbuminuria comparing individuals with and without renal hyperfiltration at baseline
| Events of microalbuminuria | Total person-years | HR (95% CI) |
||
|---|---|---|---|---|
| Unadjusted | Adjusted | |||
| 5-year HR | ||||
| No hyperfiltration | 35 | 1,500 | 1 (Ref) | 1 (Ref) |
| Hyperfiltration | 9 | 486 | 0.8 (0.4–1.7) | 0.8 (0.4–1.7) |
| 10-year HR | ||||
| No hyperfiltration | 53 | 2,744 | 1 (Ref) | 1 (Ref) |
| Hyperfiltration | 17 | 888 | 1.0 (0.6–1.7) | 1.0 (0.5–1.7) |
| 15-year HR | ||||
| No hyperfiltration | 74 | 3,574 | 1 (Ref) | 1 (Ref) |
| Hyperfiltration | 20 | 1,145 | 0.8 (0.5–1.4) | 0.9 (0.6–1.4) |
Hyperfiltration is defined as exceeding the 97.5th percentile of cystatin C-GFR in a nondiabetic, similarly aged population. For women this cutoff was 149 ml/min per 1.73 m2 and for men 134 ml/min per 1.73 m2.
*Adjusted by baseline mean A1C, age at diabetes diagnosis, diabetes duration, and current cigarette smoking. Ref, referent.