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. 2009 Apr 29;4(4):e5223. doi: 10.1371/journal.pone.0005223

Figure 6. Silvestrol suppresses xenograft tumor growth.

Figure 6

A. Response of nude mice bearing early passage human MDA-MB-231 breast cancer to silvestrol. Dosing schedule is indicated at the start of Day 11. Small crosses indicate loss of 2 animals during the course of the experiment. B. Response of nude mice bearing late passage human MDA-MB-231 breast cancer to silvestrol, doxorubicin, or rapamycin. Dosing schedule is indicated at the start of Day 11. C. Xenografts were evaluated by TUNEL and immunohistochemistry for Ki67. Representative data are shown for control-treated and silvestrol-treated mice.