Table 2.

IHC Distribution PDE8B

Tissue	e15.5 (sex not determined)	p1	p10	P77
Adipose Tissue Axillae (M) Adipose Tissue Axillae (F)	+++++/−	+++++/− +++++/−	+++/− +++/−	ne ++/−
Adipose Tissue Scapulae (M) Adipose Tissue Scapulae (F)	++/−	+++++/− +++++/−	+++/− ++++/−	++/− +++/−
Adrenal Gland (M) Adrenal Gland (F)	ne	+/− +/−	ne ne	ne ne
Adipose around Blood Vessels (M) Adipose around Blood Vessels (F)	−/−	++/− +++/−	+++/− +++/−	++/− ++/−
Brain (M) Brain (F)	+/−	+/− +/−	+/+ +/+	ne ne
Stomach (M) Stomach (F)	-	++/− +++/−	+/+ +/+	ne ne
Small intestine (M) Small intestine (F)	−/−	+++/− +++/−	++/− +++/−	ne +++
Heart, Ventricle (M) Heart, Ventricle (F)	+/−	++/− ++/−	+/− +/−	−/− +/−
Kidney (M) Kidney (F)	++/−	++/− +++/−	ne ne	ne ne
Liver (M) Liver (F)	+++/−	++/−* ++/−*	++/− ++/−	+++/− +++/−
Lung, Bronchus (M) Lung, Bronchus (F)	+/−	+/− +/−	−/− +/−	−/− −/−
Skeletal Muscles (M) Skeletal Muscles (F)	+/−	−/− +/−	+/− +/−	−/− −/−
Pancreatic Islets (M) Pancreatic Islets (F)	ne	−/− −/−	−/− −/−	ne ++/−
Spleen (M) Spleen (F)	ne	+/− ++/−	ne ne	ne +/−
Testis	+/−	±	+/−	−/−

Score: ne not examined, - undetectable, + weak, +++ medium, +++++ strong immunoreaction presented as PDE8B/IgG

^*Relates to PDE8B localization in embryonic and newborn hepatic tissue in form of islets.