Figure 3. The spontaneous mouse metastasis signature is associated with poor prognosis in human lung tumor profile datasets from the Director's Challenge Consortium.

Kaplan-Meier analysis comparing the differences in risk between human lung tumors showing activation (yellow line, t-score>0) and tumors showing deactivation (blue line, t-score<0) of the mouse model metastasis signature. Datasets from the study by Shedden et al. [15] and represent four independent cohorts from (A) Memorial Sloan-Kettering Cancer Center (MSK), (B) Moffitt Cancer Center (HLM), (C) Dana-Farber Cancer Institute (CAN/DF), and (D) University of Michigan Cancer Center (MICH). (E) Kaplan-Meier analysis of tumors combined from all four datasets (N = 362).