Table 3.
Endothelial Cell Density (ECD) in Eyes without Graft Failure at Five Years
| N | Baseline Endothelial Cell Density (25th, 75th percentiles) | Five-Year Endothelial Cell Density (25th, 75th percentiles) | % Change from Baseline to Five Years (25th, 75th percentiles)b | P-valuec | |
|---|---|---|---|---|---|
| Overall | 321a | 2692 (2481- 2887) | 765 (570- 1267) | −71% (−77% to −54%) | |
| ABO Compatibility (N=322) | 0.95 | ||||
| Compatible | 196 | 2660 (2494-2878) | 783 (565-1262) | −71% (−78% to −54%) | |
| Incompatible | 125 | 2726 (2452-2904) | 742 (574-1267) | −71% (−77% to −54%) | |
| Rh Compatibility (N=298)d | 0.85 | ||||
| Compatible | 251 | 2692 (2492, 2882) | 758 (566-1282) | −70% (−78% to −53%) | |
| Incompatible | 46 | 2684 (2438, 2938) | 740 (580-1267) | −73% (−77% to −57%) | |
| ABO/Rh Compatibility (N=298)d | 0.43 | ||||
| ABO and Rh Compatible | 152 | 2687 (2508-2870) | 781 (547-1289) | −70% (−79% to −54%) | |
| ABO Compatible/Rh Incompatible | 30 | 2583 (2429-2842) | 819 (607-1382) | −70% (−76% to −48%) | |
| ABO Incompatible/Rh Compatible | 99 | 2700 (2448-2899) | 742 (578-1212) | −71% (−77% to −52%) | |
| Neither ABO nor Rh Compatible | 16 | 2866 (2542-3035) | 701 (551-1102) | −75% (−80% to −64%) | |
a
Data are from an ancillary study that only involves a subset of CDS subjects; this analysis excludes subjects with a graft failure by five years.
b
Percent change from baseline = ECD at five years minus ECD at baseline divided by ECD at baseline and multiplied by 100%. A negative number indicates loss of cells.
c
ECD values not normally distributed; comparisons based on ranks. Rank scores transformed to have normal distribution (van der Waerden scores). P-values generated for % change from baseline to five years.
d
Rh data missing for 24 donor-recipient pairs.