Figure 5.

Resistance of sequence T with continuous TP of gene ‘mlr4742’ to nucleotides' substitutions. We selected a base in sequence T in a random manner and then substituted it, also in a random manner, by one of the nucleotides a, t, c or g (with probability of each being equal to 0.25). Thereafter, we estimated statistical significance of obtained sequence according to Equation (2). As follows from figure, statistical significance of TP decreases relatively slow during mutations' accumulation. For example, 10% difference from the original sequence still allows revealing TP at statistically significant level.