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. Author manuscript; available in PMC: 2009 Apr 21.
Published in final edited form as: J Invest Dermatol. 2007 Oct 18;128(4):917–925. doi: 10.1038/sj.jid.5701099

Figure 2. Soluble tracer moves up to and through SC interstices in CRAMP −/− epidermis.

Figure 2

In wt epidermis, lanthanum tracer outward egress (indicated by direction of curved arrows) is blocked at level of SG (a), while tracer breaches the SG–SC interstices, and focally even above that level, in CRAMP−/− epidermis (c). Six hours after acute barrier disruption by tape stripping, tracer egress is again impeded at level of outer SG in wt epidermis (b, curved arrows), indicating restoration of normal barrier function. Yet, abundant tracer still traverses the entire SC, primarily via the interstices, in CRAMP−/− epidermis (d, arrows). (a–d) Osmium tetroxide post-fixation. Bars=1 μm (a and c); 0.5 μm (b); and 5 μm (c).