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. Author manuscript; available in PMC: 2009 Apr 21.
Published in final edited form as: J Invest Dermatol. 2007 Oct 18;128(4):917–925. doi: 10.1038/sj.jid.5701099

Figure 4. Abnormalities LB secretory system in CRAMP −/− epidermis.

Figure 4

(a, c, and e) CRAMP−/− epidermis. (b and d, inset) wt epidermis. Under basal conditions, CRAMP−/− epidermis reveals abnormalities in contents of individual LB (c, single arrows). In contrast, wt epidermis has LB with replete contents (d, inset, arrowheads). In the CRAMP−/− mouse epidermis, there are non-lamellar clefts within secreted LB contents at the SG–SC interface (a, asterisks; c and e, double arrows). In wt epidermis, transformation of secreted LB contents into lamellar bilayers already occurs at SG–SC interface, as demonstrated in (b) (arrows). (a and b) Ruthenium textroxide post-fixation; (c and d) osmium tetroxide post-fixation. Bars=0.2 μm (a and b); 1 μm (c and e); and 0.1 μm (d, inset).