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. Author manuscript; available in PMC: 2009 Apr 21.
Published in final edited form as: J Invest Dermatol. 2007 Oct 18;128(4):917–925. doi: 10.1038/sj.jid.5701099

Figure 5. Delayed and incomplete formation of lamellar bilayers in CRAMP −/− epidermis.

Figure 5

In wt epidermis under basal conditions, secreted LB contents transform into lamellar bilayers within the SG–SC interface (b, solid arrows). In contrast, secreted lamellar contents remain partially untransformed several layers above SG-SC interface (a and c, open arrows), within SC interstices of CRAMP−/− mice. Moreover, lamellar bilayers, when present in SC of k.o. mice, fail to fill interstices (a, solid arrows). (a–c) Ruthenium textroxide post-fixation. Bars=0.2 μm.