Table 1. General criteria for global responses to antifungal therapy.

Outcome, response	Criteria
Success
Complete response	Survival within the prespecified period of observation, resolution of all attributable symptoms and signs of disease and radiological abnormalities, and mycological evidence of eradication of disease
Partial response	Survival within the prespecified period of observation, improvement in attributable symptoms and signs of disease and radiological abnormalities, and evidence of clearance of cultures or reduction of fungal burden, as assessed by a quantitative and validated laboratory marker
Failure
Stable responsea	Survival within the prespecified period of observation and minor or no improvement in fungal disease, but no evidence of progression, as determined on the basis of a composite of clinical, radiological, and mycological criteria
Progression of fungal disease	Evidence of progressive fungal disease based on a composite of clinical, radiological, and mycological criteria
Death	Death during the prespecified period of evaluation, regardless of attribution

^aIn certain invasive fungal diseases (e.g., invasive mold diseases), stabilization of fungal disease during periods of severe immunocompromise provides evidence of efficacy of treatment and may be a reasonable short-term therapeutic goal until immune recovery occurs.