Table 4.

Methylation Status of CpG Islands Located Within the Differentially Methylated Regions in Chromosomes 13, 18, 21, X, and Y

CHR*	Trimester	Hyper/hypo (+/−)†	Genic CpGs	Nongenic CpGs	Total no.	Promoter CpGs	% Of promoter CpGs‡
13	First	+	17	7	24	11	45.8
13	First	−	226	84	310	102	32.9
13	Third	+	74	26	100	31	31.0
13	Third	−	57	25	82	21	25.6
18	First	+	13	5	18	6	33.3
18	First	−	166	90	256	65	25.4
18	Third	+	30	12	42	15	35.7
18	Third	−	102	60	162	28	17.3
21	First	+	0	1	1	0	0.0
21	First	−	220	41	261	121	46.4
21	Third	+	4	4	8	1	12.5
21	Third	−	90	37	127	49	38.6
X	First	+	2	1	3	0	0.0
X	First	−	592	103	695	414	59.6
X	Third	+	5	1	6	0	0.0
X	Third	−	609	93	702	460	65.5
Y	First	+	3	2	5	0	0.0
Y	First	−	49	21	70	35	50.0
Y	Third	+	28	33	61	3	4.9
Y	Third	−	12	11	23	8	34.8

Methylation status of genic, nongenic, and promoter CpG islands in chromosomes 13, 18, 21, X, and Y. 

^*Chromosome. 

^†Hypermethylated/hypomethylated. 

^‡Percentage of promoter CpGs compared with the total number of differentially methylated CpG islands.