Table 8.
Example of Regions Found to Have Opposite Methylation Status between 1st and 3rd Trimester Placental DNA or Being Differentially Methylated at a Specific Gestational Age Compared with Whole Blood DNA
| Chr* | Gene name | Meth. status 1st TR_PL† | Meth. status 3rd TR_PL‡ |
|---|---|---|---|
| 13 | ALG5 | Hypomethylated | Nondifferentially methylated |
| 13 | C13orf3 | Nondifferentially methylated | Hypomethylated |
| 13 | EBPL | Hypomethylated | Nondifferentially methylated |
| 13 | BRCA2 | Hypomethylated | Hypermethylated |
| 13 | C13orf21 | Hypomethylated | Hypermethylated |
| 18 | CPLX4 | Nondifferentially methylated | Hypomethylated |
| 18 | CTDP1 | Hypomethylated | Nondifferentially methylated |
| 18 | MCART2 | Hypomethylated | Nondifferentially methylated |
| 18 | ME2 | Hypomethylated | Nondifferentially methylated |
| 21 | SUMO3 | Hypomethylated | Nondifferentially methylated |
| 21 | WRB | Hypomethylated | Nondifferentially methylated |
*
Chromosome.
†
Methylation status of 1st trimester placenta.
‡
Methylation status of 3rd trimester placenta.