Figure 4.

Western blot and quantitative real-time PCR analysis show the amount of desmin protein in different tissues from normal and noise-exposed animals. A: Desmin protein expression in whole cochlear lateral wall and retina in guinea pig. B: Desmin protein expression in cochlear stria vascularis and retina in mice. C: Quantitative real-time PCR analysis shows mRNA levels for Desmin at different time points after noise exposure. The mRNA level of Desmin is significantly increased at 30 minutes of noise exposure and 1 hour of noise exposure as well as on the 2nd day after an additional 3 hours of noise exposure (n = 10, **P_{30 minutes} < 0.01, **P_{60 minutes} < 0.01, **P_{2 days} < 0.01). GP, guinea pig; MS, mouse.