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. 2009 May;174(5):1827–1836. doi: 10.2353/ajpath.2009.080464

Figure 4.

Figure 4

Proteinuria is less severe in SPARC−/− mice following induction of passive nephrotoxic nephritis. Total urinary protein excretion in SPARC+/+ and SPARC−/− was measured in a 12-hour urine collection. Proteinuria at baseline was similar between the two groups. While proteinuria was significantly increased in SPARC+/+ mice at day 7 and day 21 following disease induction (#P < 0.01 vs. baseline), no significant increase was noted in SPARC−/− mice. Furthermore, proteinuria in the SPARC+/+ group was significantly increased at day 7 versus the SPARC−/− group (*P < 0.05), and this trend persisted at day 21 (P = 0.06).