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Regulation of expression of SOCS-1 by androgen in (A) PC3-AR, (B) LNCaP-IL-6− and (C) parental LNCaP ATCC cells. The cells were treated with increasing concentrations of the synthetic androgen methyltrienolone (R1881) for 72 hours and SOCS-1 levels were determined by Western blot. The results are representative of three independent experiments.
