Table 1.

PEAR Inclusion and Exclusion Criteria

Inclusion Age 17-65 years Average* home DBP > 85 mmHg AND office DBP > 90 mmHg

Exclusion Office or average* home DBP > 110 mmHg Office or average* home SBP > 180 mmHg Secondary forms of hypertension (including sleep apnea) Treatment with three or more antihypertensive drugs Screening office SBP > 170 mmHg during antihypertensive treatment Isolated systolic hypertension Concomitant diseases treated with BP lowering medications Heart rate < 55 beats/min (in the absence of beta-blocker therapy) Known cardiovascular disease (including history of angina pectoris, heart failure, cardiac pacemaker, myocardial infarction, revascularization procedure, stroke or TIA), Diabetes mellitus (Type 1 or 2) or screening fasting blood glucose > 126 mg/dl Serum creatinine > 1.5 mg/dl in males and 1.4 mg/dl in females Primary renal disease Pregnancy or lactation History of Raynaud’s syndrome Chronic treatment with BP-elevating drugs (including nonsteroidal antiinflammatory drugs, COX-2 inhibitors, oral contraceptives) Drug or alcohol use likely to affect study protocol adherence Upper arm circumfurence ≥ 42 cm (due to limits with the home BP monitor cuff) Abnormal liver enzymes (AST, ALT or alkaline phosphatase > 2.5 time the upper limit of normal)

^*Average home BP in week prior to visit