Table III.
Candidate Genes for Antihypertensive & Adverse Responses to Diuretics & β-blockers
| Name | HUGO Gene Symbol | Chromosomal Location |
|---|---|---|
| Sympathetic Nervous System | ||
| β1-adrenergic receptor | ADRB1 | 10q24-q26 |
| β2-adrenergic receptor | ADRB2 | 5q32-q34 |
| α1A-adrenergic receptor | ADRA1A | 8p21 |
| α1B-adrenergic receptor | ADRA1B | 5q33 |
| α 2A-adrenergic receptor | ADRA2A | 10g24.q26 |
| α 2B-adrenertic receptor | ADRA2B | 2 |
| α 2C-adrenergic receptor | ADRA2C | 4p16.1 |
| Dopamine receptor, D1 | DRD1 | 5q35.1 |
| G protein αs | GNAS1 | 20q13.2 |
| Phosphodiesterase III | PDE3A | 12p12 |
| Adenylate cyclase 5 | ADCY5 | 3q13.2-g21 |
| Adenylate cyclase 6 | ADCY6 | 12q12-g13 |
| β-adrenergic receptor kinase 1 (GRK2) | ADRBK1 | 11cen-g13 |
| G protein coupled receptor kinase 5 (GRK5) | GPRK5 | 10q24-gter |
| G protein coupled receptor kinase 4 (GRK4) | GPR2L | 4p16.3 |
| β-arrestin 1 | ARRB1 | 11q13 |
| Dopamine β-hydroxylase | DBH | 9q34 |
| Catechol-O-methyltransferase | COMT | 22q11.2 |
| Monoamine oxidase A | MAOA | Xp11.23 |
| Renin-Angiotensin-Aldosterone System | ||
| Angiotensinogen | AGT | 1q42-43 |
| Renin | REN | 1q32 |
| Angiotensin converting enzyme | ACE | 17q23 |
| Angiotensin II receptor, type 1 | AGTR1 | 3q21-q25 |
| Aldosterone synthase | CYP11B2 | 8q21 |
| Aldosterone receptor | NR3C2 | 4g31.1 |
| 11β-hydroxysteriod dehydrogenase | HSD11B2 | 16q22 |
| Natriuretic peptides/receptors | ||
| Atrial natriuretic peptide | NPPA | 1p36.2 |
| Natriuretic peptide receptor A | NPR1 | 1q21-q22 |
| Brain natriuretic peptide | NPPB | 1p36.2 |
| Endothelial Systems | ||
| Nitric oxide synthase, endothelial | NOS3 | 7q36 |
| Endothelin-1 | EDN1 | 6p24-p23 |
| Endothelin-2 | EDN2 | 1p34 |
| Endothelin receptor A | EDNRA | 4 |
| Endothelin receptor B | EDNRB | 13q22 |
| Sodium Transport Systems | ||
| Na+-H+ antiporter, amiloride-sensitive | SLC9A3 | 5p15.3 |
| Na+-K+-2Cl- cotransporter, bumetanide-sensitive | SLC12A1 | 15q15-q21.1 |
| Na+-Cl- cotransporter, thiazide-sensitive | SLC12A3 | 16q13 |
| Epithelial sodium channel: | ||
| α-subunit | SCNN1A | 12p13 |
| β-subunit | SCNN1B | 16p13-p12 |
| γ-subunit | SCNN1G | 16p13-p12 |
| NEDD4 | NEDD4L | 15q |
| α-adducin | ADD1 | 4p16.3 |
| β-adducin | ADD2 | 2p14-p13 |
| γ1 –adducin | ADD3 | 1-q24.2-q24.3 |
| G protein β3 –subunit | GNB3 | 12p13 |
| Ion regulation systems | ||
| Sarcoendoplasmic reticulum calcium ATPase | ATP2A2 | 12q23-q24.1 |
| Ryanodine receptor 2, cardiac | RYR2 | 1q42.1-q43 |
| L type Calcium channel α1c subunit | CACNA1C | 12p13.3 |
| Calcium channel β1 subunit | CACNB2 | 10p12 |
| Ca-activated K channel β1 | KCNMB1 | 5q34 |
| Potassium inwardly-rectifying channel | KCNJ1 | 11q24 |
| Chloride channel, kidney, B | CLCNKB | 1p36 |
| Protein kinase, lysine deficient 1 | PRKWNK1 | 12p13 |
| Protein kinase, lysine deficient 4 | PRKWNK4 | 17q21-g22 |
| Glucose and lipid regulation | ||
| Peroxisome proliferative activated receptor | PPARG | 3p25 |
| ATP-binding cassette, C8 | ABCC8 | 11p15.1 |
| Transcription factor 1, hepatic; albumin proximal factor | TCF1 | 12q24.2 |
| Hepatocyte nuclear factor 4, alpha | HNF4A | 20q12-g13.1 |
| Uncoupling protein 2 | UCP2 | 11q13 |
| Calpain 10 | CAPN10 | 2q37.3 |
| Hepatic lipase | LIPC | 15 q21-q23 |
| B3-adrenergic receptor | ADRB3 | 8p12-p11.2 |
| Glucagon receptor | GCGR | 17q25 |
| Cholesteryl ester transfer protein | CETP | 16q21 |
| Apolipoprotein E | APOE | 19q13.2 |
| Lipoprotein lipase | LPL | 8p22 |
| Lecithin-cholesterol acyltransferase | LCAT | 16g22.1 |
| Paraoxonase 1 | PON1 | 7q21.3 |
| Paraoxonase 2 | PON2 | 7q21.3 |
| LDL receptor | LDLR | 19p13.2 |